Mitochondrial Dysfunction in Idiopathic Parkinson Disease
Identifieur interne : 001E78 ( Main/Exploration ); précédent : 001E77; suivant : 001E79Mitochondrial Dysfunction in Idiopathic Parkinson Disease
Auteurs : W. Davis Parker Jr. [États-Unis] ; Russell H. SwerdlowSource :
- The American Journal of Human Genetics [ 0002-9297 ] ; 1998.
English descriptors
- KwdEn :
Abstract
SummaryDisordered mitochondrial metabolism may play an important role in a number of idiopathic neurodegenerative disorders. The question of mitochondrial dysfunction is particularly attractive in the case of idiopathic Parkinson disease (PD), since Vyas et al. recognized in the 1980s that the parkinsonism-inducing compound N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a mitochondrial toxin. The unique genetic properties of mitochondria also make them worthy of consideration for a pathogenic role in PD, as well as in other late-onset, sporadic neurodegenerative disorders. Although affected persons occasionally do provide family histories that suggest Mendelian inheritance, the vast majority of the time these diseases appear sporadically. Because of unique features such as heteroplasmy, replicative segregation, and threshold effects, mitochondrial inheritance can allow for the apparent sporadic nature of these diseases.
Url:
DOI: 10.1086/301812
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mitochondrial Dysfunction in Idiopathic Parkinson Disease</title><author><name sortKey="Parker Jr, W Davis" sort="Parker Jr, W Davis" uniqKey="Parker Jr W" first="W. Davis" last="Parker Jr.">W. Davis Parker Jr.</name></author><author><name sortKey="Swerdlow, Russell H" sort="Swerdlow, Russell H" uniqKey="Swerdlow R" first="Russell H." last="Swerdlow">Russell H. Swerdlow</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E77F1301590A54F1729DA98209927E61BF3C27A8</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1086/301812</idno><idno type="url">https://api.istex.fr/document/E77F1301590A54F1729DA98209927E61BF3C27A8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F98</idno><idno type="wicri:Area/Main/Curation">000E13</idno><idno type="wicri:Area/Main/Exploration">001E78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mitochondrial Dysfunction in Idiopathic Parkinson Disease</title><author><name sortKey="Parker Jr, W Davis" sort="Parker Jr, W Davis" uniqKey="Parker Jr W" first="W. Davis" last="Parker Jr.">W. Davis Parker Jr.</name><affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Address for correspondence and reprints: Dr. W. Davis Parker, Jr., Department of Neurology, University of Virginia School of Medicine, Davis Wing, Room B437, Charlottesville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Swerdlow, Russell H" sort="Swerdlow, Russell H" uniqKey="Swerdlow R" first="Russell H." last="Swerdlow">Russell H. Swerdlow</name><affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Human Genetics</title><title level="j" type="abbrev">AJHG</title><idno type="ISSN">0002-9297</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="758">758</biblScope><biblScope unit="page" to="762">762</biblScope></imprint><idno type="ISSN">0002-9297</idno></series><idno type="istex">E77F1301590A54F1729DA98209927E61BF3C27A8</idno><idno type="DOI">10.1086/301812</idno><idno type="PII">S0002-9297(07)60964-1</idno><idno type="ArticleID">60964</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Mitochondrial disease</term><term>Parkinson disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">SummaryDisordered mitochondrial metabolism may play an important role in a number of idiopathic neurodegenerative disorders. The question of mitochondrial dysfunction is particularly attractive in the case of idiopathic Parkinson disease (PD), since Vyas et al. recognized in the 1980s that the parkinsonism-inducing compound N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a mitochondrial toxin. The unique genetic properties of mitochondria also make them worthy of consideration for a pathogenic role in PD, as well as in other late-onset, sporadic neurodegenerative disorders. Although affected persons occasionally do provide family histories that suggest Mendelian inheritance, the vast majority of the time these diseases appear sporadically. Because of unique features such as heteroplasmy, replicative segregation, and threshold effects, mitochondrial inheritance can allow for the apparent sporadic nature of these diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><noCountry><name sortKey="Swerdlow, Russell H" sort="Swerdlow, Russell H" uniqKey="Swerdlow R" first="Russell H." last="Swerdlow">Russell H. Swerdlow</name></noCountry><country name="États-Unis"><region name="Virginie"><name sortKey="Parker Jr, W Davis" sort="Parker Jr, W Davis" uniqKey="Parker Jr W" first="W. Davis" last="Parker Jr.">W. Davis Parker Jr.</name></region><name sortKey="Parker Jr, W Davis" sort="Parker Jr, W Davis" uniqKey="Parker Jr W" first="W. Davis" last="Parker Jr.">W. Davis Parker Jr.</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E77F1301590A54F1729DA98209927E61BF3C27A8
|texte= Mitochondrial Dysfunction in Idiopathic Parkinson Disease
}}
| This area was generated with Dilib version V0.6.23. |  |